Life sciences

Life sciences services

Microarray analysis Gene & miRNA expression Array-CGH SNP DNA methylation Protein arrays	Next-generation sequencing analysis Whole genome & exome sequencing RNA-seq ChIP-seq
Biodatabase mining Combine your results with existing knowledge Genomic databases Experiment databases	Custom projects Integrate workflows into your infrastructure Method development Modelling and simulation

High-throughput data analysis

Microarray and sequencing analysis services include:

• Experimental design consulting
• Preprocessing, normalization and quality control
• Statistical analysis: differential expression, variant calling, etc.
• Annotation with biodatabases
• Gene Ontology & pathway analysis
• Upload to ArrayExpress/GEO (academic projects)

Our analysis workflow is illustrated in a breast cancer case.

Biodatabase mining

Find additional support for your results or discover new hypotheses from published knowledge, such as:

• Genomic and protein databases: Ensembl, NCBI/Entrez, Gene Ontology, Pathway Commons, WikiPathways, PINA
• Experiment databases: ArrayExpress, GEO, The Cancer Genome Atlas, Cancer Cell Line Encyclopedia
• Publication databases: PubMed

Custom projects

• Integrate analysis workflows into your infrastructure. Enabling software technologies include R, Anduril, KNIME, Pegasus, Taverna or your preference.
• Custom bioinformatics method development: tailor-made algorithms for your problem
• Modelling and simulation of biochemical pathways
• Suggest other ideas: info@significo.fi